About iCC

The last 10 years have witnessed an explosion in research centered on bioactive sphingolipids; especially ceramide, sphingosine, and sphingosine phosphate. Current investigation in this field is beginning to yield significant insight into the regulation of sphingolipid metabolism and its function and exciting possibilities for therapeutic applications. For example, most enzymes of sphingolipid metabolism have been identified molecularly. Functionally, ceramide is emerging as a key regulator of eukaryotic stress responses with roles in cell aging, apoptosis, and differentiation whereas sphingosine phosphate appears to play key roles in angiogenesis and vascular biology. Ceramide analogs and pharmacologic regulators of ceramide metabolism have implications in the treatment of cancer, thrombosis/re-stenosis, inflammatory diseases, aging, and immune disorders. The iCC aims at bringing together world leaders in these areas of research into a common forum that enhances the exchange and development of ideas.


The 1st  meeting (formerly the Charleston Ceramide Conference or CCC) was held at the Wild Dunes Resort on the Isle of Palms in South Carolina, November 14th to 17th, 2001. Since then, the meetings have been held biennially at the following locations:

2nd Lake Como, Italy

3rd Isle of Palms, SC

4th Pacific Grove, CA

5th Charleston, SC

6th Villars, Switzerland

7th Montauk, Long Island, NY

8th Izmir, Turkey

The conference is founded with the goal of bringing together laboratories with the common interest being ceramide and sphingolipid research. Primarily a graduate student and postdoc forum for presentation, the conference was organized to create a relaxed environment in which to foster a lively exchange of ideas and perspectives.